Summary

This is a study that may eventually lead to saving many limbs. This has an implacation in the patients
ability to continue as productive citizens without burdening the state. the treatment cost much less
than surgery. the health budget may go down.

Objectives

To assess the effectiveness of prostaglandin E1 (PGE1) on preventing major lower limb amputation in
patients with critical limb ischaemia not suitable for revascularization.
Secondary objectives
1. To assess the rate of wound healing in patients with non-revascularizable chronic limb threatening ischaemia
2. To assess the reduction of rest pain in patients with non-revascularizable chronic limb threatening
ischaemia
3. To assess the overall mortality

Major Equipment Facilitated by Grant