nrc

Geo-environmental and clinical profile of Moragahakanda, newly settled area with relation to chronic kidney disease of uncertain etiology (CKDu)

NRC Grant:  16-106

Dr. Rajitha Hanarasinghe
Faculty of Medicine
University of Peradeniya
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Area of Research:Geo-environmental and clinical profile of Moragahakanda, newly settled area with relation to chronic kidney disease of uncertain etiology (CKDu)
Status:Ongoing

 

objectives

The proposed research identifies the baseline of geochemistry and clinical biochemistry features of farmers from non-endemic regions who are resettled in Moragahakanda. Hence, they will be exposed to similar climatic, occupational, ecological features. This will facilitate to investigate if this group of people would develop CKDu and if so, the progression rate and etiology relying on the information obtained from geochemical and biochemical data.

overview

CKDu has become an endemic disease mostly represented in the dry zone of Sri Lanka. The majority of the patients are middle age males who are predominantly farmers. There have been many causes proposed for etiology yet, due to the lack of scientific significant data conclusion is difficult. At present, patients are diagnosed for CKDu by urine albumin urea levels, serum creatinine levels, clinical history and size and shapes of the kidneys by ultra sound scanning. Majority of the patients when diagnosed are of stage 3, 4 and end stage. Most of the stage 1 and 2 patients are misdiagnosed. There is a greater possibility that medical and lifestyle intervention could progress the lifespan of stage 1 and 2 patients more than the stage 3, 4 and end stage. Hence, early detection is promising to maintain the wellbeing of patients. This study will investigate the bio-clinical data of people who are potentially healthy and are related to agricultural occupation. Hence, they are exposed to similar climatic, environmental and occupational features of endemic areas. Biological samples of a systematic group will be analysed routinely for variations. Samples such as food, water, soil which are connected to the environment, occupational and lifestyle that they are exposed will also be analysed to see a relationship. This could potentially, give information about variations in the biological samples and environment, lifestyle or occupation they are connected to. A retrospective study could identify the early stages and potentially could identify the causes of disease progression. Hence, by lifestyle, educational and therapeutic intervention disease progression could be decreased and therefore, disease management.

Studying the disease progression, there could be possibilities to identify the etiology and further therapeutic interventions.