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Effect of endocrine distrupturing fungicide "Mancozeb" (metal ethylene-bis- dithiocarbamate) on human endometrial receptivity and fertility

NRC Grant: 13-059

Dr. S. Kodithuwakku
Dept. of Animal Science
Faculty of Agriculture
University of Peradeniya
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Area of Research: Biotechnology & Medical Science
Status: Ongoing

 

Objectives

  1. a) To investigate the effects of endocrine disrupting fungicide mancozeb on human endometrial receptivity. b) Identification of mancozeb or its residue in body fluids of women having sub fertility problems using High Pressure Liquid Chromatography (HPLC). c) Investigate the effect of mancozeb on human endometrial receptivity related molecules using human endometrial biopsy explants culture system. d) Identify the endometrial receptivity markers expression in the endometrial biopsies using immunohistochemistry (IHC). e) Assess the effect of mancozeb on embryo like trophoblastic spheroids attachment using an in vitro trophoblast spheroids attachment bioassay.

 

 

You are here: Home Grants - 2013 Effect of endocrine distrupturing fungicide "Mancozeb" (metal ethylene-bis- dithiocarbamate) on human endometrial receptivity and fertility